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Mouse Anti- Human CD138- PE(100 tests)

Mouse Anti- Human CD138- PE(100 tests)

CD138, also known as Syndecan-1, is a transmembrane heparin sulfate proteoglycan that binds type I collagen. The relative molecular mass of CD138 is found to vary between 20-95 kDa due to the presence of a variable number of GAG modifications on each CD138 molecule. This protein appears to mediate binding of cells to the extracellular matrix. Among mature tissues, CD138 is expressed on simple and stratified epithelia, endothelial cells, and fibroblasts. 2,3 While stratified keratinocytes express CD138, their malignant transformation suppresses CD138 expression. Wound repair processes alter patterns of CD138 expression. Among hematopoietic cells, CD138 is expressed by immunoglobulin-negative pre-B cells in the bone marrow, immature B cells and by terminally differentiated plasma cells in lymphoid organs. CD138 expression has not been observed on mature, circulating peripheral B lymphocytes, however.4-7 CD138 is also strongly expressed by multiple myeloma-derived cell lines and elevated levels of CD138 are present in the serum of patients with multiple myeloma, a negative prognostic indicator for the disease.8

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SPECIFICATIONS

Size

100 tests

Hosts

Mouse

Clone

SB55a

Format

R- phycoerythrin Conjugate (R- PE)

Presku

OASB01161

Isotype

IgG2a

SUPPLIER INFO

Aviva Systems Biology Incorporated

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