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Mouse Anti- Human CD107b/LAMP- 2- PE(100 tests)

Mouse Anti- Human CD107b/LAMP- 2- PE(100 tests)

CD107b, also known as lysosomal-associated membrane protein 2 (LAMP-2), is a heavily glycosylated, type I transmembrane protein that constitutes the major sialoglycoproteins on lysosomal membranes. It is a ligand for galaptin, an S-type lectin present in extracellular matrix, through its recognition of acetyllactosamine oligosaccharide chains, and is a ligand for E-selectin-mediated cell adhesion. CD107b is expressed by granulocytes, T cells, macrophages, dendritic cells, activated platelets tonsillar epithelium and some tumor cell lines, including U937 and KG1a. It is also a widely expressed intracellular antigen. LAMP-2 may function in protecting the inner surface of the lysosomal membrane by forming a barrier to lysosomal hydrolases. The upregulation of both CD107a and CD107b on the surface of tumor cell lines has been associated with their enhanced metastatic potential, where they may increase adhesion to extracellular matrix and endothelium.1-7

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SPECIFICATIONS

Size

100 tests

Hosts

Mouse

Clone

H4B4

Format

R- phycoerythrin Conjugate (R- PE)

Presku

OASB01170

Isotype

IgG1

SUPPLIER INFO

Aviva Systems Biology Incorporated

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