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Mouse Anti- Human Caspase- 3- HRP(1.0 mL)

Mouse Anti- Human Caspase- 3- HRP(1.0 mL)

The Caspases are a family of cysteine proteases that induce apoptosis in response to a variety of intra- and extracellular stimuli. These enzymes are synthesized as inactive precursors which become cleaved at aspartate-specific sites upon induction of apoptosis2. Caspase 3 (CPP32, Yama, apopain) is one of the best characterized caspases in terms of specificity and function in apoptosis. It is a ubiquitously expressed protein in mammals and is highly prevalent in cells with lymphocytic origins, indicating a regulatory role in the immune system3,4. Caspase 3 plays a critical role during embryonic development by inducing morphogenetic cell death in the mammalian brain and has also been linked to chromatin condensation, DNA fragmentation and blebbing3,5-7. The SB71b monoclonal antibody detects a band at ~32 and 17 kD, corresponding to the full length and cleaved forms of Caspase 3.

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SPECIFICATIONS

Size

1.0 mL

Hosts

Mouse

Clone

SB71b

Format

Horseradish Peroxidase (HRP) Conjugate

Presku

OASB01361

Isotype

IgG2a

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