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MMP 1 Human - Recombinant Human Matrix Metalloproteinase-1 (2ug)

MMP 1 Human - Recombinant Human Matrix Metalloproteinase-1 (2ug)

Product Introduction: MMP-1 (interstitial collagenase) can break down a wide range of substrates including types I, II, III, VII, VIII, and X collagens as well as L-Selectin, pro-TNF, IL-1?, IGFBP-3, IGFBP-5, casein, gelatin, ?1 antitrypsin, myelin basic protein, pro-MMP2 and pro-MMP9. A significant function of MMP-1 is the degradation of fibrillar collagens in extracellular matrix remodeling. MMP-1 is expressed in fibroblasts, keratinocytes, endothelial cells, monocytes and macrophages. MMP1 can be divided into a number of distinct domains: a prodomain which is cleaved on activation, a catalytic domain containing the zinc binding site and a short hinge region with a carboxyl terminal domain. MMP1 is part of a cluster of MMP genes which localize to chromosome 11q22.3.
Product Description: MMP-1 Human Recombinant produced in HEK293 cells is a proform of the Human MMP1 (Met1-Asn469) and fused with a ployhistide tag at the C-terminus, having an Mw of 52kDa. MMP-1 is purified by proprietary chromatographic techniques.

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SPECIFICATIONS

Size

2ug

Format

Sterile Filtered colorless solution.

Presku

OOPA00113

Alternative Names

Interstitial collagenase; Fibroblast collagenase; Matrix metalloproteinase-1; MMP-1; MMP1; CLG; CLGN.

SUPPLIER INFO

Aviva Systems Biology Incorporated

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