MLL (10F8) Antibody

MLL (Histone-lysine N-methyltransferase) is a 430 kDa protein that regulates embryonal and hematopoietic development. Eukaryotic RNA polymerase II mediates the synthesis of mature and functional messenger RNA. This is a multistep process, called the transcription cycle, that includes five stages: preinitiation,Porcineromoter, clearance, elongation and termination. Elongation is thought to be a critical stage for the regulation of gene e, Xenopus/Amphibian,pression. ELL functions as an RNA polymerase II elongation factor that increases the rate of transcription by suppressing transient pausing by RNA polymerase II. Also, ELL is thought to regulate cellular proliferation. ELL is abundantly e, Xenopus/Amphibian,pressed in peripheral blood leukocytes, skeletal muscle,Porcinelacenta and testis, and has lower e, Xenopus/Amphibian,pression in spleen, thymus, heart, brain, lung, kidney, liver and ovary.