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MLF1 Human - Recombinant Human Myeloid Leukemia Factor 1 (5ug)

MLF1 Human - Recombinant Human Myeloid Leukemia Factor 1 (5ug)

Product Introduction: Myeloid leukemia factor 1 (MLF1) is a member of the MLF family, and is a widely expressed negative regulator of cell cycle progression functioning upstream of the tumor suppressor p53. MLF1 hinders the erythropoietin-induced erythroid terminal differentiation by averting cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. MLF1 generally functions in multi-potent progenitor cells, and its dysregulation may be to some extent responsible for leukemogenesis. Translocations between the MLF1 gene and nucleophosmin are linked to myelodysplastic syndrome and acute myeloid leukemia.
Product Description: MLF1 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 288 amino acids (1-268 a.a.) and having a molecular mass of 32.8kDa (Molecular weight on SDS-PAGE will appear higher). The MLF1 is purified by proprietary chromatographic techniques.

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SPECIFICATIONS

Size

5ug

Format

Sterile Filtered colorless solution.

Presku

OPPA00169

Alternative Names

Myeloid leukemia factor 1; Myelodysplasia-myeloid leukemia factor 1; MLF1.

SUPPLIER INFO

Aviva Systems Biology Incorporated

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