Reactivities: | Human |
Presku: | AAP42038 |
Size: | 100ug |
Weight: | 22kDa |
Gene: | 4255 |
Format: | Lyophilized powder |
Target: | MGMT is involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA.MGMT repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. |