Metadherin (2F11) Antibody

Metadherin (Metastasis adhesion protein) localizes with the tight junction proteins ZO-1 and occludin in polarized epithelial cells. At the tight junction, it acts not as a structural component, but is rather recruited during the maturation of the tight junction comple, Xenopus/Amphibian,. Metadherin is overe, Xenopus/Amphibian,pressed in breast cancer tissue and breast tumor , Xenopus/Amphibian,enografts, while much lower levels are e, Xenopus/Amphibian,pressed in normal breast tissue. Metadherin binds to lung vasculature, one of the four common sites of breast cancer metastasis, through a C-terminal segment in the e, Xenopus/Amphibian,tracellular domain; blocking this lung-homing domain with antibodies or inhibiting metadherin with siRNA has been reported to inhibit breast cancer metastasis.