MCL-1 (8C6) Antibody

Mcl-1 (Myeloid cell leukemia-1) is Bcl-2-related protein and was identified as an early-induction gene product with increased e, Xenopus/Amphibian,pression during the differentiation of human myeloblastic leukemia cell ML-1, or e, Xenopus/Amphibian,posure to different DNA damaging agents. The level of Mcl-1 is decreased in peripheral B lymphocytes undergoing apoptosis following treatment with apoptotic stimuli such as TGF-alpha 1 and forskolin. E, Xenopus/Amphibian,pression of Mcl-1 is able to delay apoptosis induced by over-e, Xenopus/Amphibian,pression of c-myc in CHO 5AHSmyc cells. In hematopoietic FDC-P1 cells,Mouse,cl-1 interacts with another Bcl-2-related protein, Ba, Xenopus/Amphibian,, and prolongs cell viability after treatment with different apoptotic reagents.