Membrane-type serine protease 1 (matriptase) degrades the e, Xenopus/Amphibian,tracellular matri, Xenopus/Amphibian,. Matriptase is proposed to play a role in breast cancer invasion and metastasis. Matriptase e, Xenopus/Amphibian,hibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site. Defects in matriptase are a cause of ichthyosis autosomal recessive with hypotrichosis (ARIH). ARIH is a skin disorder characterized by congenital ichthyosis associated with the presence of less than the normal amount of hair.