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MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4) Blocking Peptide (the N terminal of protein) (100ug)

MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4) Blocking Peptide (the N terminal of protein) (100ug)

Supplier: Aviva Systems Biology Incorporated
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This is a synthetic peptide designed for use in combination with anti-MAP4K4 antibody (Catalogue #: ARP49031_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Presku: AAP49031
Size: 100 ug
Weight: 133kDa
Gene: 9448
Format: Lyophilized powder
Target: MAP4K4 is the serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. MAP4K4 appears to act upstream of the JUN N-terminal pathway.The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified.
Alternative names: FLH21957; FLJ10410; FLJ20373; FLJ90111; HGK; KIAA0687; NIK
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