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MANF (mesencephalic astrocyte-derived neurotrophic factor) Blocking Peptide (the C terminal of MANF)(100ug)

MANF (mesencephalic astrocyte-derived neurotrophic factor) Blocking Peptide (the C terminal of MANF)(100ug)

Supplier: Aviva Systems Biology Incorporated
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This is a synthetic peptide designed for use in combination with anti-MANF Antibody (ARP59608_P050), made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Reactivities: Human
Presku: AAP59608
Size: 100ug
Weight: 21kDa
Gene: 7873
Format: Lyophilized powder
Target: MANF is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of MANF gene increases susceptibility to ER stress-induced death and promotes cell proliferation. The protein was initially thought to be longer at the N-terminus and to contain an arginine-rich region but transcribed evidence indicates a smaller open reading frame that does not encode the arginine tract. The presence of polymorphisms in the arginine-rich region, including a specific mutation that changes the previously numbered codon 50 from ATG to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus not tumor-related.
Alternative names: ARMET; ARP; MGC142148; MGC142150
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