Lrp8 (low density lipoprotein receptor-related protein 8, apolipoprotein e receptor) Blocking Peptide (the middle region of Lrp8)(100ug)

Supplier: Aviva Systems Biology Incorporated

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Description
Additional Information

This is a synthetic peptide designed for use in combination with anti-Lrp8 Antibody(ARP44306_P050), made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.

Reactivities:	Mouse
Presku:	AAP44306
Size:	100ug
Weight:	110kDa
Gene:	16975
Format:	Lyophilized powder
Target:	Lrp8 is the cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Lrp8 binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Lrp8 is highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. Lrp8 may also function as an endocytic receptor.
Alternative names:	4932703M08Rik; AA921429; AI848122; Lr8b; apoER2