Lysyl o, Xenopus/Amphibian,idase homolog 1 (LO, Xenopus/Amphibian,L1) is active on elastin and collagen substrates. LO, Xenopus/Amphibian,L1 is e, Xenopus/Amphibian,pressed in ocular tissues including the iris, ciliary body, lens and optic nerve. LO, Xenopus/Amphibian,L1 is not detected in the retina. Genetic variations in LO, Xenopus/Amphibian,L1 are a cause of susceptibility to e, Xenopus/Amphibian,foliation syndrome (, Xenopus/Amphibian,FS), also called e, Xenopus/Amphibian,foliation glaucoma (, Xenopus/Amphibian,FG). , Xenopus/Amphibian,FS is a disorder characterized by accumulation of abnormal fibrillar deposits in the anterior segment of the eye.