AbFluor™ dyes are a series of highly water-soluble fluorescent dyes spanning the visible and near-infrared spectrum for Labeling biomolecules, especially proteins and nucleic acids. AbFluor™ dyes bear the core structures of different fluorescent dye core structures that cover the fluorescence spectrum from UV to NIR. Innovative modifications to the core structure makes AbFluor™ dyes superior to other commercial dyes with many innovative novel features. AbFluor™ 405 has improved brightness and photostability for the 405 nm laser line, which is super alternative to DyLight 405, Alexa Fluor 405. It yields biologically more specific antibody conjugates and less background, better compatibility with common instruments.