LHRH Antibody

Luteinizing hormone-releasing hormone (LHRH, GnRH, Gonadoliberin, Luliberin) is a decapeptide neurohormone produced mainly in the preoptic area of the hypothalamus, secreted at the median eminence into the portal blood, and carried to the gonadotropin-releasing hormone receptor (GnRHR). GnRHR is found on gonadotrope cells of the pituitary gland, and other organs. In the pituitary, stimulation of the G-protein coupled GnRHR results in secretion of gonadotropins LH and FSH, which are involved in such reproductive functions as follicular growth, ovulation, and corpus leteum maintenance in the female, and spermatogenesis in the male. LHRH release is regulated by various transmitters/hormones including norepinephrine, GABA, glutamate, dopamine, Kisspeptin, estrogen. Disorders in LHRH activity include Polycystic ovary syndrome (high) and Kallmann syndrome (low). Clinical use (Factrel, Lutrepulse, Lutrelef, Relisorm) requires infusion pumps because of its short half-life.

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SPECIFICATIONS

Catalog Number

250515

Size

0.1 mg

Applications

IHC

Reactivities

Hum, Mouse, Rabbit

Format

Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

P Type

Rabbit Polyclonal Antibody

Antigen

KLH-conjugated synthetic peptide encompassing a sequence within the center region of human LHRH.

Isotype

Rabbit Ig

Accession

P01148

Additional Info

LHRH; LHRH/GnRH; Progonadoliberin-1; Progonadoliberin I; Gonadoliberin-1; Gonadoliberin I; Luteinizing hormone-releasing hormone I; Gonadotropin-releasing hormone I; GnRH-1; Luliberin I; Gonadorelin; GNRH