LHRH Antibody

Luteinizing hormone-releasing hormone (LHRH, GnRH, Gonadoliberin, Luliberin) is a decapeptide neurohormone produced mainly in the preoptic area of the hypothalamus, secreted at the median eminence into the portal blood, and carried to the gonadotropin-releasing hormone receptor (GnRHR). GnRHR is found on gonadotrope cells of the pituitary gland, and other organs. In the pituitary, stimulation of the G-protein coupled GnRHR results in secretion of gonadotropins LH and FSH, which are involved in such reproductive functions as follicular growth, ovulation, and corpus leteum maintenance in the female, and spermatogenesis in the male. LHRH release is regulated by various transmitters/hormones including norepinephrine, GABA, glutamate, dopamine, Kisspeptin, estrogen. Disorders in LHRH activity include Polycystic ovary syndrome (high) and Kallmann syndrome (low). Clinical use (Factrel, Lutrepulse, Lutrelef, Relisorm) requires infusion pumps because of its short half-life.