Lactadherin, a novel adhesion molecule, also known as MFG-E8, is a widely distributed glycoprotein (~50 kD) that has been found in macrophages, dendritic cells, vascular smooth muscle cells, astrocytes, microglia, breast carcinioma cells, and also in breast milk and in and around blood vessels. Lactadherin contains an N-terminal EGF-like motif with an inserted RGD cell adhesion sequence; it also contains a C-terminal sequence sharing homology with the discoidin family of lectin domains, including the phospholipid-binding domains of blood clotting factors V and VIII. Lactadherin promotes RGD-dependent cell attachment of a variety of cell types, but most notably of cells that express the integrin heterodimer, alpha v beta 3. The C1/C2 domain binds specifically to phosphotidylserine. Mounting evidence has shown that Lactadherin plays a far more important role than just protecting the newborn, a function originally identified. Lactadherin functions as an anticoagulant by blocking phosphatidylserine-containing membrane sites for blood coagulation proteins. It is also involved in cell death by recognizing phosphatidylserine that is exposed on apoptotic cells. Lactadherin is also crucial in VEGF-dependent neovascularization and has been identified as an important target for the modulation of neovascularization. In addition, Lactadherin was identified as a novel target for radioimmunotherapy in breast cancer and is also important in the initiation and/or progression of Alzheimer’s disease. BioLegend’s LEGEND MAX(TM) Mouse Lactadherin ELISA Kit is a sandwich Enzyme-Linked Immunosorbent Assay (ELISA), in which, a mouse Lactadherin specific polyclonal antibody is pre-coated on a 96-well strip-well plate. This Kit is specifically designed for the quantitation of Mouse Lactadherin from cell culture supernatant, serum, plasma or other bodily fluids. It is ready-to-use, accurate, and cost-effective.
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