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LEAF(TM) Purified anti-human CD183 (CXCR3)

LEAF(TM) Purified anti-human CD183 (CXCR3)

Cat no: 353718

Supplier: BioLegend
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Human CXCR3, also known as GPR9, is a chemokine receptor that binds CXCL9, CXCL10, and CXCL11. It is a 38 kD seven-pass transmembrane receptor coupled to G-protein. CXCR3 is highly expressed by T lymphocytes (Th1), natural killer cells (NK cells), dendritic cells, mast cells, alveolar macrophages, eosinophils, and human airway epithelial cells. CXCR3 is important for effector lymphocyte recruitment into inflamed tissue in various inflammatory and autoimmune diseases, such as chronically inflamed human liver, Crohn's disease, rheumatoid arthritis, multiple sclerosis, and inflammatory skin diseases.
Catalogue number: 353718
Reactivities: Human
Hosts: Mouse
Applications: Block/Neutralize/Inhibit, Flow Cytometry
Size: 500 microg
Clone: G025H7
Gene: 2833
Dilutions: Each lot of this antibody is quality control tested by blocking. Chemotaxis of human CXCR3-transfected BaF3 cells was performed in the presence of 20 ng/ml of recombinant CXCL11. Addition of LEAF(TM) purified anti-human CXCR3 (clone G025H7) inhibits migration of hCXCR3 transfected BaF3 cells (ED50=0.15 microg/ml). For immunofluorescent staining, it is recommended that the reagent be titrated for optimal performance for each application. Other formats of this clone are quality tested for flow cytometry.
Storage buffer: The antibody solution should be stored undiluted at 4C. This LEAF(TM) solution contains no preservative; handle under aseptic conditions.
Concentration: 1 mg/ml
Antigen: Human CXCR3 transfectants
Isotype: Mouse IgG1, kappa
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: CXCR3, G protein-coupled receptor 9 (GPR9), CKR-L2, CKRL2, IP10 receptor (IP10-R, IP10R, IP 10 R), Mig receptor (Mig-R, MigR) CMKAR3
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