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Ldlrap1 (low density lipoprotein receptor adaptor protein 1 ) Blocking Peptide (the C terminal of Ldlrap1)(100ug)

Ldlrap1 (low density lipoprotein receptor adaptor protein 1 ) Blocking Peptide (the C terminal of Ldlrap1)(100ug)

Supplier: Aviva Systems Biology Incorporated
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This is a synthetic peptide designed for use in combination with anti-Ldlrap1 Antibody (ARP55309_P050), made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Reactivities: Human, Mouse
Presku: AAP55309
Size: 100ug
Weight: 29kDa
Gene: 100017
Format: Lyophilized powder
Target: Ldlrap1 is an adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). It may be required for LDL binding and internalization but not for receptor clustering in coated pits. It may facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. Ldlrap1 may also be involved in the internalization of other LDLR family members. Ldlrap1 binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface.
Alternative names: AA691260; ARH2; Arh; Arh1; FHCB1; FHCB2
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