Presku: | AAP37760 |
Size: | 100 ug |
Weight: | 86kDa |
Gene: | 26013 |
Format: | Lyophilized powder |
Target: | L3MBTL is the homolog of a protein identified in Drosophila as a suppressor of malignant transformation of neuroblasts and ganglion-mother cells in the optic centers of the brain. L3MBTL is localized to condensed chromosomes in mitotic cells. Overexpression of this gene in a glioma cell line results in improper nuclear segregation and cytokinesis producing multinucleated cells.This gene encodes the homolog of a protein identified in Drosophila as a suppressor of malignant transformation of neuroblasts and ganglion-mother cells in the optic centers of the brain. This gene product is localized to condensed chromosomes in mitotic cells. Overexpression of this gene in a glioma cell line results in improper nuclear segregation and cytokinesis producing multinucleated cells. Alternatively spliced transcript variants encoding different isoforms have been identified. |
Alternative names: | DKFZp586P1522; FLJ41181; H-L(3)MBT; KIAA0681; L3MBTL1; dJ138B7.3 |