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KPNA1 Antibody (OAPB01179)

KPNA1 Antibody (OAPB01179)

Karyopherin, a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex by an energy requiring, Ran-dependent mechanism. The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC. KPNA1, also known as importin alpha 5, is the alpha subunit of karyopherin, which forms a complex with importin subunit beta-1 and functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. It is ubiquitously expressed and polyubiquitinated in the presence of RAG1. KPNA1 interacts with various virus nucleoproteins, including those of Ebola and influenza.

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SPECIFICATIONS

Size

0.1 mg

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Presku

OAPB01179

Target

Importin alpha 5

Alternative Names

KPNA1; Karyopherin alpha 1 Nucleoprotein interactor 1; Importin alpha 5; IPOA5; RAG cohort protein 2; RCH2; SRP1; NPI-1

SUPPLIER INFO

Aviva Systems Biology Incorporated

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