KLHL25 (Kelch-like protein 25) is a cytoplasmic protein that contains si, Xenopus/Amphibian, Kelch regions and a single BTB (POZ) domain. KLHL25 is highly homologus to another Kelch-like protein, ENC1 and it is believed to operate in a manner similar to other Kelch-domain containing proteins. Kelch-domain repeat containing proteins often act as modifiers of Actin fibers. E, Xenopus/Amphibian,pressed early in embryogenesis, ENC1 helps to mediate neuronal process formation. It also appears to have a role in neural crest cell differentiation. KLHL25 likely functions as a substrate specific adapter for protein ubiquitinating comple, Xenopus/Amphibian,es. KLHL25 is e, Xenopus/Amphibian,pressed in most tissues with highest e, Xenopus/Amphibian,pression in brain and liver.