KDM3A (1E12) Antibody

JMJD1A (Lysine-specific demethylase 3A) is a zinc finger protein that contains a jumonji domain and may play a role in hormone-dependent transcriptional activation. JMJD1A functions as a mono- and dimethylation-specific demethylase, binding iron and alpha-ketoglutarate as cofactors and demethylating Lysine 9 of Histone H3. This suggests that JMJD1A plays a central role in the histone code and participates in nuclear hormone receptor-based transcriptional regulation. In addition, JMJD1A plays an important role in the regulation of cell growth during development and in chromatin regulation. JMJD1A directly regulates the e, Xenopus/Amphibian,pression of TNP1 and Protamine 1 (proteins required for the proper packaging and condensation of sperm chromatin), therefore,Porcinelays an essential role in spermatogenesis.