Supplier:
Aviva Systems Biology IncorporatedITGB3BP (integrin beta 3 binding protein (beta3-endonexin)) Blocking Peptide (the N terminal of protein) (100ug)
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SPECIFICATIONS
Size
100 ug
Format
Lyophilized powder
Presku
AAP54999
Target
ITGB3BP is a transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. ITGB3BP acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. It induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. ITGB3BP may also act as an inhibitor of cyclin A-associated kinase. ITGB3BP may be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.
Weight
20kDa
Gene Id
23421
Alternative Names
CENP-R; CENPR; HSU37139; NRIF3; TAP20
SUPPLIER INFO
Applications
ELISA, WB
Hosts
Mouse
Applications
IHC
Hosts
Mouse
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