Reactivities: | Human |
Presku: | AAP63955 |
Size: | 100ug |
Weight: | 16kDa |
Gene: | 3674 |
Format: | Lyophilized powder |
Target: | ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. |
Alternative names: | CD41; CD41B; GP2B; GPIIb; GTA; HPA3 |