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IRS-4 Antibody
ABBIOTEC

Supplier:

ABBIOTEC

Cat no: 250729

IRS-4 Antibody

The family of insulin receptor substrates (IRS) has been reported to play an important role for signal transduction of various hormones. Four members of the IRS family have been described. Each IRS is believed to have different functions although the distinct physiological roles of each IRS are unclear. IRS-4 encodes the insulin receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS-4 interacts with cytoplasmic signaling molecules that contain SH2 domains such as IGF1R and FGFR1. IRS-4 is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation. IRS-4 is involved in the proliferation and differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation.

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SPECIFICATIONS

Catalog Number

250729

Size

0.1 mg

Applications

IHC

Reactivities

Rabbit

Format

Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

P Type

Rabbit Polyclonal Antibody

Antigen

KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of mouse IRS-4.

Isotype

Rabbit Ig

Accession

Q9Z0Y7

Additional Info

Insulin receptor substrate 4; IRS-4; 160 kDa phosphotyrosine protein; PY160; IRS4

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