IRS-1 Antibody

The family of insulin receptors substrates (IRSs) has been reported to play an important role for signal transduction of various hormones. Four members of the IRS family have been described. Each IRS is believed to have different functions; however the distinct physiological roles of each IRS are unclear. IRS-1 may mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor, IRS-1 binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit, ROCK1, UBTF and PIK3CA. Serine phosphorylation (Ser-312) of IRS-1 is a mechanism for insulin resistance. Polymorphisms in IRS-1 may be involved int he etiology of non-insulin-dependent diabetes mellitus.