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IRF3 Antibody (OAPB00261)

IRF3 Antibody (OAPB00261)

Interferons (IFN)s are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms. During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-alpha/beta genes. IRF3 is present in an inactive form in the cytoplasm of most cells. Following viral infection, IRF3 can be activated by IkappaB kinase-epsilon and TANK-binding kinase 1 (TBK1), whereupon IRF3 translocates to the nucleus. IRF3 can also be activated by stimulation of toll-like receptor 3 (TLR3) by dsRNA. IRF3 exists as at least two distinct isoforms.

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SPECIFICATIONS

Size

0.1 mg

Applications

ELISA, ICC, WB

Hosts

Rabbit

Reactivities

Hum

Presku

OAPB00261

Target

interferon regulatory factor 3

Alternative Names

IRF3

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