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INPP5D (inositol polyphosphate-5-phosphatase, 145kDa ) Blocking Peptide (the C terminal of INPP5D)(100ug)

INPP5D (inositol polyphosphate-5-phosphatase, 145kDa ) Blocking Peptide (the C terminal of INPP5D)(100ug)

Supplier: Aviva Systems Biology Incorporated
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This is a synthetic peptide designed for use in combination with anti-INPP5D Antibody (ARP61033_P050), made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Reactivities: Human
Presku: AAP61033
Size: 100ug
Weight: 131kDa
Gene: The peptide is characterized by mass spectroscopy
Format: Lyophilized powder
Target: This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Alternative names: MGC104855; MGC142140; MGC142142; SHIP; SHIP1; SIP-145; hp51CN
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