IKBKE (6B4B) Antibody

IKBKE (Inhibitor of nuclear factor kappa-B kinase subunit epsilon) is a Serine/threonine-protein kinase. The transcription factor NF?B is retained in the cytoplasm in an inactive form by the inhibitory protein I?B. Activation of NF?B requires that I?B be phosphorylated on specific serine residues, which results in targeted degradation of I?B. I?B kinase ? (IKK?),Porcinereviously designated CHUK, interacts with I?B-? and specifically phosphorylates I?B-? on the sites that trigger its degradation, serines 32 and 36. The functional IKK comple, Xenopus/Amphibian, contains three subunits, IKK?, IKK(B) and IKK? (also designated NEMO), and each appear to make essential contributions to I?B phosphorylation. IKK-i is a serine/threonine kinase that shares homology with IKK? and IKK(B). IKK-i is primarily e, Xenopus/Amphibian,pressed in immune cells and is induced by lipopolysaccharide and by proinflammatory cytokines including TNF?, IL-1 and IL-6. Overe, Xenopus/Amphibian,pression of IKK-i was shown to result in phosphorylation of I?B? on Ser32 and Ser36, and in NF?B activation, suggesting that IKK-i may act as an I?B kinase in the immune system.