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IKBKB (10A2) Antibody
ABBIOTEC

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ABBIOTEC

Cat no: 252688

IKBKB (10A2) Antibody

IKBKB (Inhibitor of kappa light polypeptide gene enhancer in B-cells kinase beta, also called IKK2/IKKB) is a member of the IKK comple, Xenopus/Amphibian, which is composed of IKK-alpha, IKK-beta, IKK-gamma and IKAP. Phosphorylation of I-Kappa-B on a serine residue by the IKK comple, Xenopus/Amphibian, frees NF-kB from I-Kappa-B and marks it for degradation via ubiquination. IKK-beta has been shown to activate NF-kB and phosphorylate IKB-alpha and beta. Phosphorylation of 2 sites at the activation loop of IKK-beta is essential for activation of IKK by TNF and IL1. Once activated, IKK-beta is autophosphorylated which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response. Additionally, IKK-beta activity can also be regulated by MEKK-1.

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SPECIFICATIONS

Catalog Number

252688

Size

0.1 ml

Applications

IHC

Reactivities

Hum

Format

Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.

P Type

Mouse Monoclonal Antibody

Antigen

Purified recombinant fragment of IKBKB e, Xenopus/Amphibian,pressed in E. coli.

Isotype

Mouse IgG1

Accession

O14920

Clonality

10A2C5B3

Additional Info

Inhibitor of nuclear factor kappa-B kinase subunit beta; I-kappa-B-kinase beta; IKK-B-beta; IkBKB; I-kappa-B kinase 2; IKK2; Nuclear factor NF-kappa-B inhibitor kinase beta; NFKBIKB; IKBKB

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