Human Sodium leak channel non-selective protein (NALCN) ELISA Kit

NALCN encodes a voltage-independent, nonselective cation channel which belongs to a family of voltage-gated sodium and calcium channels that regulates the resting membrane potential and excitability of neurons. This family is expressed throughout the nervous system and conducts a persistent sodium leak current that contributes to tonic neuronal excitability. Sodium leak channel non-selective protein forms a channelosome complex that includes G-protein-coupled receptors, UNC-79, UNC-80, NCA localization factor-1, and src family tyrosine kinases. Naturally occurring mutations in NALCN are associated with infantile neuroaxonal dystrophy, infantile hypotonia with psychomotor retardation and characteristic facies (IHPRF) syndrome, and congenital contractures of the limbs and face with hypotonia and developmental delay (CLIFAHDD) syndrome. A knockout of the orthologous gene in mice results in paralysis with a severely disrupted respiratory rhythm, and lethality within 24 hours after birth.

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SPECIFICATIONS

Catalog Number

KTE61382

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

259232

Accession

Q8IZF0

Additional Info

Human Sodium leak channel non-selective protein (NALCN) ELISA Kit has high sensitivity and excellent specificity for detection of Human NALCN. No significant cross-reactivity or interference between Human NALCN and analogues was observed.