Human Methionine aminopeptidase 2 (METAP2) ELISA Kit

Methionine aminopeptidase 2 encoded by METAP2 is a member of the methionyl aminopeptidase family. Methionine aminopeptidase 2 functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent proteins. Increased expression of METAP2 is associated with various forms of cancer, and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. Inhibitors of this gene have also been shown to be effective for the treatment of obesity. A pseudogene of METAP2 is located on chromosome 2. Several transcript variants encoding different isoforms have been found for METAP2.В

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SPECIFICATIONS

Catalog Number

KTE61643

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

10988

Accession

P50579

Additional Info

Human Methionine aminopeptidase 2 (METAP2) ELISA Kit has high sensitivity and excellent specificity for detection of Human METAP2. No significant cross-reactivity or interference between Human METAP2 and analogues was observed.