Human Killer cell immunoglobulin-like receptor 2DS4 (KIR2DS4) ELISA Kit

Using primers known to amplify HLA-C-specific NK receptors to screen clones with NK triggering activity, Bottino et al. (1996) also isolated a KIR2DS4 cDNA, which they termed KKA3. Sequence analysis revealed that KIR2DS4 encodes a deduced 304-amino acid protein with an extracellular domain similar to that of KIR2D p58 receptors; however, in the transmembrane region, there is a charged lysine residue, and the cytoplasmic tail has only 39 amino acids with no ITIM (immunoreceptor tyrosine-based inhibitory motif). KIRs with short cytoplasmic tails are associated with NK cell triggering rather than inhibition. Immunoprecipitation analysis showed that KIR2DS4 is expressed in 2 forms, one of 35 to 45 kD and the other of 55 to 58 kD. Flow cytometry analysis showed that KIR2DS4, unlike KIR2DS1 and KIR2DS2, was expressed in only a minority of individuals tested.

Prices direct from Abbkine Scientific Co.Ltd.

Quick response times

Exclusive Absave savings/discounts

SPECIFICATIONS

Catalog Number

KTE61915

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Hum

Gene Id

3809

Accession

P43632

Additional Info

Human Killer cell immunoglobulin-like receptor 2DS4 (KIR2DS4) ELISA Kit has high sensitivity and excellent specificity for detection of Human KIR2DS4. No significant cross-reactivity or interference between Human KIR2DS4 and analogues was observed.