Supplier:
Aviva Systems Biology IncorporatedHTR1B antibody - N-terminal region (AVARP13042_T100)
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SPECIFICATIONS
Size
100ug
Applications
WB
Hosts
Rabbit
Reactivities
Hum
Format
Lyophilized powder
Presku
AVARP13042_T100
Target
The pathophysiology of depression remains enigmatic, although abnormalities that involve serotonin signaling have been implicated. The serotonin 1B receptor [5-hydroxytryptamine (5-HT1B) receptor] interacts with p11. p11 increases localization of 5-HT1B receptors at the cell surface. p11 is increased in rodent brains by antidepressants or electroconvulsive therapy, but decreased in an animal model of depression and in brain tissue from depressed patients. Overexpression of p11 increases 5-HT1B receptor function in cells and recapitulates certain behaviors seen after antidepressant treatment in mice. p11 knockout mice exhibit a depression-like phenotype and have reduced responsiveness to 5-HT1B receptor agonists and reduced behavioral reactions to an antidepressant.
Weight
44kDa
Gene Id
3351
Alternative Names
S12; 5-HT1B; HTR1D2; HTR1DB; 5-HT1DB
SUPPLIER INFO
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