

Supplier:
Aviva Systems Biology IncorporatedHTR1B (5-hydroxytryptamine (serotonin) receptor 1B) Blocking Peptide (100ug)
Prices direct from Aviva Systems Biology Incorporated
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Exclusive Absave savings/discounts
SPECIFICATIONS
Size
100 ug
Format
Lyophilized powder
Presku
AAP30711
Target
The pathophysiology of depression remains enigmatic, although abnormalities that involve serotonin signaling have been implicated. The serotonin 1B receptor [5-hydroxytryptamine (5-HT1B) receptor] interacts with p11. p11 increases localization of 5-HT1B receptors at the cell surface. p11 is increased in rodent brains by antidepressants or electroconvulsive therapy, but decreased in an animal model of depression and in brain tissue from depressed patients. Overexpression of p11 increases 5-HT1B receptor function in cells and recapitulates certain behaviors seen after antidepressant treatment in mice. p11 knockout mice exhibit a depression-like phenotype and have reduced responsiveness to 5-HT1B receptor agonists and reduced behavioral reactions to an antidepressant.
Weight
44kDa
Gene Id
3351
Applications
WB
Hosts
Rabbit
Reactivities
Hum, Rat
Applications
WB
Hosts
Rabbit
Reactivities
Hum, Mouse, Bov
Applications
IHC, WB
Hosts
Rabbit
Reactivities
Hum
Applications
IHC, WB
Hosts
Rabbit
Reactivities
Hum
Applications
WB
Hosts
Rabbit
Reactivities
Hum
Applications
WB
Hosts
Rabbit
Reactivities
Hum
Applications
WB
Hosts
Rabbit
Reactivities
Hum
Applications
WB
Hosts
Rabbit
Reactivities
Hum, Mouse, Rat, Bov, Prc
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