Home  >  Products  >  HTR1B (5-hydroxytryptamine (serotonin) receptor 1B) Blocking Peptide (100ug)
HTR1B (5-hydroxytryptamine (serotonin) receptor 1B) Blocking Peptide (100ug)

HTR1B (5-hydroxytryptamine (serotonin) receptor 1B) Blocking Peptide (100ug)

Supplier: Aviva Systems Biology Incorporated
Star_fadedStar_fadedStar_fadedStar_fadedStar_faded
0 reviews | Write a Review Pencil
This is a synthetic peptide designed for use in combination with anti-HTR1B antibody (Catalogue #: AVARP13042_T100) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Presku: AAP30711
Size: 100 ug
Weight: 44kDa
Gene: 3351
Format: Lyophilized powder
Target: The pathophysiology of depression remains enigmatic, although abnormalities that involve serotonin signaling have been implicated. The serotonin 1B receptor [5-hydroxytryptamine (5-HT1B) receptor] interacts with p11. p11 increases localization of 5-HT1B receptors at the cell surface. p11 is increased in rodent brains by antidepressants or electroconvulsive therapy, but decreased in an animal model of depression and in brain tissue from depressed patients. Overexpression of p11 increases 5-HT1B receptor function in cells and recapitulates certain behaviors seen after antidepressant treatment in mice. p11 knockout mice exhibit a depression-like phenotype and have reduced responsiveness to 5-HT1B receptor agonists and reduced behavioral reactions to an antidepressant.
See Full Product Listings >