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HK2 (3D3) Antibody
ABBIOTEC

Supplier:

ABBIOTEC

Cat no: 253048

HK2 (3D3) Antibody

HK2 (He, Xenopus/Amphibian,okinase-2) is an enzyme in the he, Xenopus/Amphibian,okinase family,Porcinelaying a role in the carbohydrate metabolism. The he, Xenopus/Amphibian,okinases utilize Mg-ATP as a phosphoryl donor to catalyze the first step of intracellular glucose metabolism, the conversion of glucose to glucose- 6-phosphate. Four he, Xenopus/Amphibian,okinase isoenzymes have been identified, including he, Xenopus/Amphibian,okinase I (H, Xenopus/Amphibian,K I), he, Xenopus/Amphibian,okinase II (H, Xenopus/Amphibian,K II), he, Xenopus/Amphibian,okinase III (H, Xenopus/Amphibian,K III) and he, Xenopus/Amphibian,okinase IV (H, Xenopus/Amphibian,K IV, also designated glucokinase or GCK). He, Xenopus/Amphibian,okinases I-III each contain an N-terminal cluster of hydrophobic amino acids. Glucokinase lacks the N-terminal hydrophobic cluster. The hydrophobic cluster is thought to be necessary for membrane binding. This is substantiated by the finding that glucokinase has lower affinity for glucose than do the other he, Xenopus/Amphibian,okinases. He, Xenopus/Amphibian,okinase 2 is the predominant he, Xenopus/Amphibian,okinase isozyme e, Xenopus/Amphibian,pressed in insulin-responsive tissues such as skeletal muscle. E, Xenopus/Amphibian,pression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells.

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SPECIFICATIONS

Catalog Number

253048

Size

0.1 ml

Applications

IF, IHC

Reactivities

Hum

Format

Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.

P Type

Mouse Monoclonal Antibody

Antigen

Purified recombinant fragment of human HK2 e, Xenopus/Amphibian,pressed in E. coli.

Isotype

Mouse IgG1

Accession

P52789

Clonality

3D3

Additional Info

He, Xenopus/Amphibian,okinase-2; He, Xenopus/Amphibian,okinase type II; HK II; Muscle form he, Xenopus/Amphibian,okinase; HK2

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