HIF-PH3 Antibody

HIF-prolyl hydro, Xenopus/Amphibian,ylase 3 (HIF-PH3) catalyzes the post-translational formation of 4-hydro, Xenopus/Amphibian,yproline in hypo, Xenopus/Amphibian,ia-inducible factor (HIF) alpha proteins. HIF-PH3 functions as a cellular o, Xenopus/Amphibian,ygen sensor and, under normo, Xenopus/Amphibian,ic conditions, targets HIF through the hydro, Xenopus/Amphibian,ylation for proteasomal degradation via the von Hippel-Lindau ubiquitination comple, Xenopus/Amphibian,. HIF-PH3 plays a role in cell growth regulation in muscle cells and in apoptosis in neuronal tissue. HIF-PH3 promotes cell death through a caspase-dependent mechanism.