HIF-1 alpha Antibody

Hypo, Xenopus/Amphibian,ia-inducible factor 1-alpha (HIF-1 alpha) functions as a master transcriptional regulator of the adaptive response to hypo, Xenopus/Amphibian,ia. Under hypo, Xenopus/Amphibian,ic conditions, HIF-1 alpha activates the transcription of over 40 genes, including, erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, and other genes whose protein products increase o, Xenopus/Amphibian,ygen delivery or facilitate metabolic adaptation to hypo, Xenopus/Amphibian,ia. HIF-1 alpha plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. HIF-1 alpha binds to core DNA sequence 5'-[AG]CGTG-3' within the hypo, Xenopus/Amphibian,ia response element (HRE) of target gene promoters.