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HFE2 (hemochromatosis type 2 (juvenile)) Blocking Peptide (the N terminal of HFE2)(100ug)

HFE2 (hemochromatosis type 2 (juvenile)) Blocking Peptide (the N terminal of HFE2)(100ug)

Supplier: Aviva Systems Biology Incorporated
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This is a synthetic peptide designed for use in combination with anti-HFE2 Antibody(ARP53489_P050), made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Reactivities: Human
Presku: AAP53489
Size: 100ug
Weight: 21kDa
Gene: 148738
Format: Lyophilized powder
Target: The product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30.
Alternative names: HFE2A; HJV; JH; MGC23953; RGMC
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