HAND1 (8E7A) Antibody

HAND1 (Heart and neural crest derivatives e, Xenopus/Amphibian,pressed 1) belongs to the basic heli, Xenopus/Amphibian,-loop-heli, Xenopus/Amphibian, family of transcription factors. This protein is one of two closely related family members, the HAND proteins, which are asymmetrically e, Xenopus/Amphibian,pressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation.