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Hamster Anti- Mouse CD154/CD40L- LE/AF(0.5 mg)

Hamster Anti- Mouse CD154/CD40L- LE/AF(0.5 mg)

CD154, formerly known as CD40 ligand and gp39, is a type II integral membrane protein and a member of the tumor necrosis factor (TNF) family of ligands.1-7 It is an important accessory molecule in T cell-B cell costimulatory interactions, and is expressed predominantly on activated CD4+ T lymphocytes. It is also present on the surface of activated Th0, Th1, and Th2 T cell clones. Its expression is transient and cyclosporinsensitive. 6 The MR1 monoclonal antibody binds to murine CD154 with high affinity, blocks binding to CD40, and blocks CD154 function.1, 5 Administration of this antibody to mice blocks the ability to mount primary and secondary immune responses to TD antigens, yet does not alter the immune response to TI antigens.4

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SPECIFICATIONS

Size

0.5 mg

Applications

FC

Hosts

Ham

Clone

MR1

Format

Low Endotoxin, Azide- Free (LE/AF)

Presku

OASB01693

Isotype

IgG

SUPPLIER INFO

Aviva Systems Biology Incorporated

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