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Hamster Anti- Mouse CD152/CTLA- 4- LE/AF(0.5 mg)

Hamster Anti- Mouse CD152/CTLA- 4- LE/AF(0.5 mg)

CD152, also known as CTLA-4, is homologous to the costimulatory molecule CD28.1,2 Like CD28, the CD152 molecule binds the family of B7 counter-receptors (CD80/B7-1 and CD86/B7-2) on antigenpresenting cells.3 CTLA-4 is not expressed on resting T lymphocytes but is induced 2-3 days following T-cell stimulation via the T cell receptor (TCR) complex.1,3,4 Whereas CD28 provides a positive costimulatory signal, CD152/CTLA-4 is a negative regulator of T-cell activation, possibly by inhibiting tyrosine kinase signalling through the TCR through its association with tyrosine phosphatases such as SHP-2.1,5,6

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SPECIFICATIONS

Size

0.5 mg

Hosts

Ham

Clone

9H10

Format

Low Endotoxin, Azide- Free (LE/AF)

Presku

OASB01727

Isotype

IgG

SUPPLIER INFO

Aviva Systems Biology Incorporated

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