Supplier:
Aviva Systems Biology IncorporatedH3f3a (H3 histone, family 3A ) Blocking Peptide (the N terminal of H3f3a)(100ug)
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SPECIFICATIONS
Size
100ug
Reactivities
Hum, Mouse
Format
Lyophilized powder
Presku
AAP60983
Target
H3f3a is a variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. H3f3a constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. H3f3a is deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Weight
15kDa
Gene Id
15078
Alternative Names
H3.3A; H3f3b; MGC102150
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