Reactivities: | Human |
Presku: | AAP57281 |
Size: | 100ug |
Weight: | 40kDa |
Gene: | 55506 |
Format: | Lyophilized powder |
Target: | H2AFY2 is the variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. H2AFY2 may be involved in stable X chromosome inactivation. |
Alternative names: | macroH2A2 |