Home  >  Products  >  GUCA1A (guanylate cyclase activator 1A (retina)) Blocking Peptide (the N terminal of protein) (100ug)
GUCA1A (guanylate cyclase activator 1A (retina)) Blocking Peptide (the N terminal of protein) (100ug)

GUCA1A (guanylate cyclase activator 1A (retina)) Blocking Peptide (the N terminal of protein) (100ug)

Supplier: Aviva Systems Biology Incorporated
Star_fadedStar_fadedStar_fadedStar_fadedStar_faded
0 reviews | Write a Review Pencil
This is a synthetic peptide designed for use in combination with anti-GUCA1A antibody (Catalogue #: ARP54309_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Presku: AAP54309
Size: 100 ug
Weight: 23kDa
Gene: 2978
Format: Lyophilized powder
Target: GUCA1A(GCAP1) plays a role in the recovery of retinal photoreceptors from photobleaching. In the recovery phase, the phototransduction messeneger cGMP is replenished by retinal guanylyl cyclase-1 (GC1). GC1 is activated by decreasing Ca(2+) concentrations following photobleaching. The protein mediates the sensitivity of GC1 to Ca(2+) concentrations. GCAP1 promotes activity of GC1 at low Ca(2+) concentrations and inhibits GC1 activity at high Ca(2+) concentrations. Mutations in this gene cause autosomal dominant cone dystrophy (COD3); a disease characterized by reduced visual acuity associated with progressive loss of color vision. Mutations in this gene prohibit the inactivation of RetGC1 at high Ca(2+) concentrations; causing the constitutive activation of RetGC1 and, presumably, increased cell death. This gene is expressed in retina and spermatagonia.
Alternative names: COD3; GCAP; GCAP1; GUCA; GUCA1
See Full Product Listings >