Supplier:
Aviva Systems Biology IncorporatedGUCA1A (guanylate cyclase activator 1A (retina)) Blocking Peptide (the N terminal of protein) (100ug)
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SPECIFICATIONS
Size
100 ug
Format
Lyophilized powder
Presku
AAP54309
Target
GUCA1A(GCAP1) plays a role in the recovery of retinal photoreceptors from photobleaching. In the recovery phase, the phototransduction messeneger cGMP is replenished by retinal guanylyl cyclase-1 (GC1). GC1 is activated by decreasing Ca(2+) concentrations following photobleaching. The protein mediates the sensitivity of GC1 to Ca(2+) concentrations. GCAP1 promotes activity of GC1 at low Ca(2+) concentrations and inhibits GC1 activity at high Ca(2+) concentrations. Mutations in this gene cause autosomal dominant cone dystrophy (COD3); a disease characterized by reduced visual acuity associated with progressive loss of color vision. Mutations in this gene prohibit the inactivation of RetGC1 at high Ca(2+) concentrations; causing the constitutive activation of RetGC1 and, presumably, increased cell death. This gene is expressed in retina and spermatagonia.
Weight
23kDa
Gene Id
2978
Alternative Names
COD3; GCAP; GCAP1; GUCA; GUCA1
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