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GRAP (Human) cDNA (1ug)

GRAP (Human) cDNA (1ug)

Supplier: Aviva Systems Biology Incorporated
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The ORF of human GRAP is amplified by PCR using a high fidelity enzyme and sub-cloned into a Prokaryotic expression vector under the control of the tac promoter. The expression of the gene has been confirmed by Western blot using an anti-GRAP polyclonal antibody.
Presku: ANA11539
Size: 1ug
Gene: 10750
Target: This gene encodes a member of the GRB2/Sem5/Drk family. This member functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain.
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