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GLRB (Human) cDNA (1ug)

GLRB (Human) cDNA (1ug)

Supplier: Aviva Systems Biology Incorporated
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The ORF of human GLRB is amplified by PCR using a high fidelity enzyme and sub-cloned into a Prokaryotic expression vector under the control of the tac promoter. The expression of the gene has been confirmed by Western blot using an anti-GLRB polyclonal antibody.
Presku: ANA10532
Size: 1ug
Gene: 2743
Target: This gene encodes the beta subunit of the glycine receptor, which is a pentamer composed of alpha and beta subunits. The receptor functions as a neurotransmitter-gated ion channel, which produces hyperpolarization via increased chloride conductance due to the binding of glycine to the receptor. Mutations in this gene cause startle disease, also known as hereditary hyperekplexia or congenital stiff-person syndrome, a disease characterized by muscular rigidity. Alternative splicing results in multiple transcript variants.
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