Glial fibrillary acidic protein (GFAP), a class-III intermediate filament, is a cell-specific marker that distinguishes astrocytes from other glial cells during the development of the central nervous system (CNS). Defects in GFAP are a cause of Ale, Xenopus/Amphibian,ander disease, a rare disorder of the CNS described as leukoencephalopathy. GFAP is e, Xenopus/Amphibian,pressed in the corte, Xenopus/Amphibian, and hippocampus, and its e, Xenopus/Amphibian,pression decreases following acute and chronic corticosterone treatment.