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Gelsolin Antibody
ABBIOTEC

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ABBIOTEC

Cat no: 251751

Gelsolin Antibody

Gelsolin is a calcium-regulated, actin-modulating protein that binds to the plus ends of actin monomers and filaments,Porcinereventing monomer e, Xenopus/Amphibian,change. Gelsolin promotes the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Defects in gelsolin are the cause of amyloidosis type 5 (AMYL5), also known as familial amyloidosis Finnish type. AMYL5 is a hereditary generalized amyloidosis due to gelsolin amyloid deposition, and is typically characterized by cranial neuropathy and lattice corneal dystrophy. Most patients have modest involvement of internal organs, but severe systemic disease can develop in some individuals, causing peripheral polyneuropathy, amyloid cardiomyopathy, and nephrotic syndrome leading to renal failure.

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SPECIFICATIONS

Catalog Number

251751

Size

0.1 mg

Applications

IHC

Reactivities

Hum, Mouse, Rabbit

Format

Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 0.2% BSA with 0.09% sodium azide. Antibody was purified by anti-mouse IgG affinity chromatography.

P Type

Mouse Monoclonal Antibody

Antigen

Human plasma gelsolin.

Isotype

Mouse IgG1

Accession

P06396

Clonality

GEL-42

Additional Info

Gelsolin; Actin-depolymerizing factor; ADF; Brevin; AGEL

SUPPLIER INFO

ABBIOTEC

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